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目的探究尿激酶溶栓治疗对急性心肌梗死患者N末端B型脑利钠肽前体(NT-pro BNP)水平和左心室射血分数的影响。方法 60例行保守治疗的急性心肌梗死患者,给予尿激酶溶栓治疗,根据溶栓结果分为溶栓再通组(48例)和溶栓未再通组(12例)。比较两组患者治疗前后血浆NT-pro BNP水平和左心室射血分数变化。结果溶栓后24 h、48 h、7 d时溶栓再通组患者血浆NT-pro BNP水平均低于溶栓未再通组,差异具有统计学意义(P<0.05)。住院时两组患者左心室射血分数水平比较差异无统计学意义(t=0.147,P>0.05),溶栓后1周、1个月溶栓再通组患者血浆NT-pro BNP水平均高于溶栓未再通组,差异具有统计学意义(t=2.291、2.978,P<0.05)。结论尿激酶溶栓治疗可有效患者急性心肌梗死患者的临床症状,改善心功能,值得借鉴。
Objective To investigate the effect of urokinase thrombolytic therapy on N-terminal pro-brain natriuretic peptide (NT-pro BNP) level and left ventricular ejection fraction in patients with acute myocardial infarction. Methods Sixty patients undergoing conservative treatment of acute myocardial infarction were treated with urokinase thrombolysis. According to the results of thrombolytic therapy, they were divided into thrombolytic group (n = 48) and thrombolysis without recanalization group (n = 12). The changes of plasma NT-pro BNP level and left ventricular ejection fraction before and after treatment were compared between the two groups. Results The levels of plasma NT-pro BNP in patients receiving thrombolytic therapy at 24 h, 48 h and 7 d after thrombolysis were significantly lower than those without thrombolysis (P <0.05). There was no significant difference in left ventricular ejection fraction between the two groups when hospitalized (t = 0.147, P> 0.05). The levels of plasma NT-pro BNP in patients who underwent thrombolysis and recanalization at 1 week and 1 month after thrombolysis were significantly higher than those in the control group Suppository without reperfusion group, the difference was statistically significant (t = 2.291,2.978, P <0.05). Conclusion Urokinase thrombolytic therapy can effectively treat patients with acute myocardial infarction clinical symptoms, improve cardiac function, it is worth learning from.