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虽然第二信使环磷酸腺苷(cyclic AMP,cAMP)在生理上对心脏是有益的,但当其调控失常时在很大程度上促进心脏疾病进展。目前的证据表明,cAMP是在线粒体内产生的。然而,线粒体cAMP信号通路及其在心脏病理生理中的作用尚未知。该研究探讨在缺血/再灌注(ischemia/reperfusion,I/R)损伤情况下,由cAMP 1直接激活的线粒体交换蛋白(mitochondrial exchange protein directly activated by cAMP 1,MitEpac1)的作用。研究发现,Epac1基因切除
Although the second messenger cyclic AMP (cAMP) is physiologically beneficial to the heart, its regulation greatly contributes to the progression of heart disease. The current evidence suggests that cAMP is produced within the mitochondria. However, the mitochondrial cAMP signaling pathway and its role in cardiac pathophysiology are unknown. This study explored the role of mitochondrial exchange protein directly activated by cAMP 1 (MitEpac1) directly activated by cAMP 1 in the context of ischemia / reperfusion (I / R) injury. The study found that Epac1 gene excision