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一、肾中毒的病理生理学机制 1.肾中毒的定义肾中毒的发生率与内科医师在遇到与氨基甙有关的肾损害时是否接受肾中毒的定义有关。因为肾中毒的含义常常被误解,在这个关键问题上必须加以澄清。肾功能紊乱,直到75～90％的肾功能已失去这一段时间往往有“无症状”的倾向。这是一种很不幸的临床现象,因为缺乏适当临床试验的病人常常会给他们的肾脏带来严重的不可挽回的损害。在与氨基甙有关的肾中毒情况下,医生为临床症状而等待显然是十分不当的。
First, the pathophysiology of renal toxicity 1. The definition of renal toxicity The incidence of renal toxicity and physicians in the face of aminoglycoside-related renal damage whether to accept the definition of renal toxicity. Because the meaning of kidney poisoning is often misunderstood, this crucial issue must be clarified. Renal dysfunction, until 75 to 90% of the renal function has been lost during this period tend to have “asymptomatic” tendency. This is a very unfortunate clinical phenomenon because patients who lack proper clinical trials often have serious, irreversible damage to their kidneys. In the case of aminoglycoside-related nephrotoxicity, it is obviously inappropriate for doctors to wait for clinical symptoms.