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自 198 6年Murry等[1] 在犬心模型上证实预先给予几次短暂心肌缺血 /再灌注 (I/R)能提高心肌对随后长时间冠脉阻断所致损伤耐受力 ,并称此现象为缺血预适应 (ischemicprecondition ,IP )。在随后人们大量的研究中发现多次短暂I/R不仅对心脏随后
Since 1988, Murry et al. [1] demonstrated that myocardial ischemia / reperfusion (I / R) was preconditioned in canine heart model to enhance the myocardial tolerance to subsequent long-term coronary occlusion This phenomenon is called ischemic preconditioning (IP). Subsequent many people in the study found that multiple ephemeral I / R was not only for the heart subsequently