氨茶碱是治疗支气管哮喘的常用药物,其毒性较大,治疗指数小,而且个体差异大,用法不易掌握。按常规用法,许多患者疗效欠佳或发生毒性反应。 近年来对氨茶碱的代谢动力学研究发现,氨茶碱的血中浓度和不良反应有密切关系。它治疗支气管哮喘最佳浓度为10～20μg/ml,低于10μg/ml时疗效很差,而超过20μg/ml时常出现一系列毒性反应。氨茶碱的半衰期一般为5～6小时。临床药理研究还发现,为了达到上述有 Aminophylline is a commonly used drug for the treatment of bronchial asthma, its toxicity, therapeutic index is small, and the individual differences, the use of difficult to grasp. As usual, many patients are ineffective or have toxic reactions. In recent years, the study of aminophylline pharmacokinetics found that the blood concentration of aminophylline and adverse reactions are closely related. It is the best treatment for bronchial asthma 10 ~ 20μg / ml, less than 10μg / ml when the curative effect is poor, and more than 20μg / ml often appear a series of toxic reactions. Aminophylline half-life is generally 5 to 6 hours. Clinical pharmacology research also found that in order to achieve the above