约20%-40%的糖尿病(DM)患者最终发展成糖尿病肾病(DN),据资料统计在西方国家终末期肾病(end-stagerenal failure,ESRF)的40%左右为DN所致,因此DN的诊断尤其是早期诊断对于DM患者的预后十分重要。传统的理论认为DN主要病理改变为肾小球硬化—肾小球基底膜肥厚及细胞外基质的沉积 About 20% -40% of diabetic patients eventually develop diabetic nephropathy (DN). According to the statistics, about 40% of end-stage renal failure (ESRF) in western countries is caused by DN, Diagnosis, especially early diagnosis, is important for the prognosis of patients with DM. The traditional theory that the main pathological changes of DN as glomerular sclerosis - glomerular basement membrane hypertrophy and extracellular matrix deposition