论文部分内容阅读
本文研究了镉、汞、铅在试管内对肝微粒体混合功能氧化酶活力和脂质过氧化作用的影响。结果表明,这三种金属均直接抑制肝微粒体苯胺羟化酶活力,降低细胞色素P-450含量,增加无活性细胞色素P-420 含量,同时可使肝微粒体脂质过氧化作用加强,并都存在明显的剂量-反应关系。从而提示镉、汞、铅在试管内可能是通过激活膜脂质的过氧化使肝微粒体混合功能氧化酶活力降低。
In this paper, the effects of cadmium, mercury and lead on the mixed functional oxidase activity and lipid peroxidation of liver microsomes were studied in vitro. The results showed that all three metals directly inhibited the activity of aniline hydroxylase in liver microsomes, decreased the content of cytochrome P-450, increased the content of inactive cytochrome P-420 and enhanced the lipid peroxidation of liver microsomes. And there is a clear dose-response relationship. It was suggested that cadmium, mercury and lead in the test tube may reduce the activity of liver microsomal mixed-function oxidase through the activation of membrane lipid peroxidation.