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用肾上腺素所致肺水肿模拟临床上常见的神经源性肺水肿,如颅脑创伤,高原缺氧,脑血管病等所致肺水肿就属此类,具有动力性和非动力性双重机制,既有肺毛细血管压力升高,又有肺毛细血管通透性增高,大鼠在数分钟内迅速死亡.而从股静脉注射山莨菪成(30mg·kg-1)和川芎嗪(120mg·Kg-1)进行预防,绝大部分动物均不形成肺水肿。为了探讨PGI2与TXA2在此模型中的作用,我们先后测定了用山莨菪碱和川芎嗪预防后大鼠颈动脉血和支气管肺泡灌洗液6-Keto-PGF1α和TXB2的含量变化,结果表明,山莨菪碱和川芎嗪能有效地降低血浆和支气管肺泡灌洗液的TXB2含量(P<0.01),对6-Kito-PGF1α无明显影响(P<0.05),推测山莨菪碱和川芎嗪在预防肺水肿的发生中,TXA2参与动力学和非动力学机制来达到PGI2与TXA2的平衡。P<0.01速恢复,存活时间>30min者30min时取血,收集支气管肺泡灌洗液(BALF);第四组为川芎嗪预防组,先于股静脉注射川芎嗪120mg·kg-1作为预防,再注射上述过量Adr,动物经一度呼吸困难甚至暂停后迅速恢复,存活者注射Adr后30min取血,收集BALF。颈总动脉的血直接?
Pulmonary edema caused by adrenergic simulation of common clinical neurogenic pulmonary edema, such as traumatic brain injury, high altitude hypoxia, cerebrovascular disease caused by such pulmonary edema belong to this class, with a dynamic and non-dynamic dual mechanism, Both pulmonary capillary pressure, pulmonary capillary permeability increased, the rapid death of rats within a few minutes. However, injection of anisodamine into the femoral vein (30 mg · kg-1) and ligustrazine (120 mg · Kg-1) prevented the formation of pulmonary edema in most animals. In order to investigate the role of PGI2 and TXA2 in this model, we determined the levels of 6-Keto-PGF1α and TXB2 in carotid and bronchoalveolar lavage fluid after preventive treatment with anisodamine and ligustrazine. The results showed that, Anisodamine and ligustrazine effectively reduced TXB2 content in plasma and bronchoalveolar lavage fluid (P <0.01), and had no significant effect on 6-Kito-PGF1α (P <0.05), suggesting that anisodamine and In the prevention of pulmonary edema by ligustrazine, TXA2 participates in kinetic and non-kinetic mechanisms to achieve the balance between PGI2 and TXA2. P <0.01 speed recovery, survival time> 30min 30min blood was collected, bronchoalveolar lavage fluid (BALF); the fourth group of ligustrazine preventive group, prior to the femoral vein injection of ligustrazine 120mg · kg-1 as Prevention, re-injection of the above excess Adr, animals once breathing difficulties or even quickly resumed after suspension, survivors 30min after injection of Adr blood, collect BALF. Carotid artery blood directly?