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纤维性肺泡炎呈慢性进行性炎症,以损伤和纤维化为特征.目前认为,原始刺激物的局部免疫反应激活巨噬细胞,使其吸引和活化中性粒细胞(PMN),PMN 又分泌蛋白酶和活性氧,损伤间质细胞和结缔组织,吸引成纤维细胞并使之增生。已证明在支气管肺泡灌洗液中,巨噬细胞、PMN 和嗜酸细胞增加。纤维性肺泡炎患者的巨噬细胞(AM)能自发地分泌多种因子,如纤维粘连蛋白、血小板生长因子(PDGF)、胰岛素样生长因子-1(IGF-I,可致
Fibroblastic alveolitis is a chronic, progressive inflammation characterized by damage and fibrosis It is presently believed that the local immune response of the primary stimulus activates macrophages to attract and activate neutrophils (PMNs), which in turn secrete proteases And reactive oxygen species, damaging interstitial cells and connective tissue, attracting and proliferating fibroblasts. It has been demonstrated that macrophages, PMN and eosinophils are increased in bronchoalveolar lavage fluid. Macrophages (AMs) from patients with fibrosing alveolitis spontaneously secrete a variety of factors such as fibronectin, platelet-derived growth factor (PDGF), insulin-like growth factor-1 (IGF-I)