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Behcet病(下称BD)目前认为属于结缔组织病的近缘性疾病,发病机理与免疫调节功能障碍有关。其主要病理组织学变化为广泛的血管炎症,影响全身诸多系统。其中有些可造成严重后遗症或危及生命(如心血管、神经系统、眼睛病变等)。而目前的治疗方法各异,疗效也不确切,为此特收集近年来有关文献,作一综述供参考。一、发病机理近年来关于本病发病机理有一些较新的论述,现概要介绍如下: (一)遗传因素:主要认为BD发病与HLA抗原系统的类型有关。HLA-B_5和眼型BD,HLA-B_(12)和粘膜皮肤型BD,HLA-B_(27)和关节炎型BD间的关系比较密切。具有这些HLA抗原类型者,BD发病的可能性较大。 (二)细菌变态反应:对患者进行细菌
Behcet’s disease (hereinafter referred to as BD) is currently considered as a related disease of connective tissue disease, pathogenesis and immunomodulatory dysfunction. The main histopathological changes for a wide range of vascular inflammation, affecting many systems throughout the body. Some of these can cause serious sequelae or life-threatening conditions (such as cardiovascular, nervous system, eye disease, etc.). The current treatment methods vary, the effect is not precise, for this special collection of relevant literature in recent years, for a review for reference. First, the pathogenesis In recent years, the pathogenesis of this disease have some newer discourses, are summarized as follows: (A) genetic factors: mainly that BD pathogenesis and HLA antigen system type. The relationship between HLA-B_5 and ocular BD, HLA-B_ (12) and mucosal cutaneous BD, HLA-B_ (27) and arthritic BD was relatively close. With these types of HLA antigens, BD is more likely to develop. (B) bacterial allergy: Bacteria to patients