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糖皮质激素广泛的抗炎作用是治疗慢性阻塞性肺疾病(COPD)的主要理论依据,同时糖皮质激素可上调β2受体表达,增强β2受体激动剂功能和减轻因COPD引起的全身炎症反应[1]。近年来,国内外应用吸入激素如布地耐德雾化悬液(普米克令舒)治疗COPD急性加重,但由于观察的病例数较少,吸入激素在COPD急性加重中的作用尚需进一步研究[2]。
The broad anti-inflammatory effect of glucocorticoids is the main theoretical basis for the treatment of chronic obstructive pulmonary disease (COPD), and glucocorticoid up-regulates the expression of β2 receptor, enhances the function of β2 receptor agonist and alleviates the systemic inflammatory response caused by COPD [1]. In recent years, the domestic and international application of inhaled hormones such as Budenitis atomized suspension (Pulmicort respules) in the treatment of acute exacerbation of COPD, but the observed small number of cases, the role of inhaled hormones in acute exacerbation of COPD needs further study [ 2].