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游离脂肪酸(FFA)在胰岛素抵抗中可诱发β细胞的凋亡,并可降低胰岛素介导的肝脏和骨骼肌细胞的葡萄糖摄取和利用,减弱胰岛素对肝糖原产生的抑制作用[1]。脂肪因子如TNFs、脂联素、瘦素等在FFA介导的胰岛素抵抗中也起着重要作用[2]。以往的研究显示,在高脂诱导的胰岛素抵抗(IR)模
Free fatty acid (FFA) induces beta-cell apoptosis in insulin resistance and reduces insulin-mediated glucose uptake and utilization in liver and skeletal muscle cells, attenuating the inhibitory effect of insulin on hepatic glycogen production [1]. Adipogenic factors such as TNFs, adiponectin, leptin and others also play an important role in FFA-mediated insulin resistance [2]. Previous studies have shown that in high fat-induced insulin resistance (IR) mode