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许多证据表明人类乳头状瘤病毒(HPV)的某些类型在诱发一些人体癌症的特殊类型方面起了明显的作用。本文选择了19例上气消化道鳞癌患者的组织标本应用Southern blot杂交方法测定HPV DNA,并进行了分析。19例中计口腔6例、咽5例、喉3例、鼻及鼻窦5例;其中男性13例,女性6例,年龄40～82岁。12例标本为原发肿瘤,7例为颈部转移灶。上气消化道癌中HPV感染主要存在于口腔及喉部;而作者在19例中证实2例存在HPV感染,其中1例上颌窦癌发现类似于HPV_(16)DNA的排列顺序,另1例扁桃体癌存在有HPV_(16)DNA。2例均为高分化鳞癌。多见于男性,一般认为与
There is a lot of evidence that certain types of human papillomavirus (HPV) play a significant role in inducing certain types of human cancers. In this paper, 19 specimens of patients with gastroenteric squamous cell carcinoma of the upper gastrointestinal tract were selected for Southern blot analysis of HPV DNA and analyzed. In 19 cases, there were 6 cases of oral cavity, 5 cases of pharynx, 3 cases of larynx, and 5 cases of nose and sinuses. There were 13 males and 6 females, aged 40-82 years old. Twelve specimens were primary tumors, and 7 were cervical metastases. HPV infection in upper gastro-intestinal cancer is mainly found in the oral cavity and larynx. The authors confirmed the presence of HPV infection in 2 of 19 cases. Among them, 1 case of maxillary sinus cancer was found to be similar to the order of HPV 16 DNA, and the other 1 case. The presence of HPV_(16) DNA in tonsillar cancer. Both cases were well-differentiated squamous carcinomas More common in men, generally think of