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目的探讨拜糖平与二甲双胍治疗初诊Ⅱ型糖尿病的疗效及药物副作用。方法将我院2009年12月-2013年4月160例初诊Ⅱ型糖尿病患者随机分为两组各80例,观察组采取拜糖平治疗,对照组采取二甲双胍治疗,比较两组患者的临床疗效及药物副作用。结果治疗后两组患者的FBG(空腹血糖)、PBG(餐后2h血糖)较治疗前均出现明显下降(P<0.01),但观察组PBG下降更为明显,组间差异显著(P<0.05);对照组FBG下降更为明显,组间差异显著(P<0.05);两组患者治疗前后空腹胰岛素及餐后2h胰岛素均未出现明显变化,差异无统计学意义(P>0.05);观察组16例出现腹胀、排气次数增多,2例腹泻,对照组15例出现腹泻、腹部不适,但均能耐受,治疗后期大多数症状明显减轻或消失。结论拜糖平与二甲双胍治疗Ⅱ型糖尿病疗效显著,且药物副作用轻微,值得临床推广应用。
Objective To investigate the curative effect and drug side effects of ethambutol and metformin in the treatment of newly diagnosed type 2 diabetes mellitus. Methods 160 cases of newly diagnosed type 2 diabetes mellitus in our hospital from December 2009 to April 2013 were randomly divided into two groups of 80 cases. The observation group was treated with albuterol, while the control group was treated with metformin. The clinical efficacy was compared between the two groups And drug side effects. Results After treatment, FBG (fasting blood glucose) and PBG (2h postprandial blood glucose) in both groups were significantly lower than those before treatment (P <0.01), but the decrease of PBG was more obvious in the two groups (P <0.05 (P <0.05). There was no significant difference in fasting insulin and postprandial 2h insulin between the two groups before and after treatment (P> 0.05), and the difference was not statistically significant In the 16 cases, abdominal distension, number of excretion increased, 2 cases of diarrhea, and 15 cases of control group had diarrhea and abdominal discomfort, but all of them were tolerant. Most of the symptoms were relieved or disappeared at the later stage of treatment. Conclusion The treatment of type 2 diabetes with bevredine and metformin has significant curative effect and mild side effects. It is worthy of clinical application.