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目的进一步研究吡喹酮对裂头蚴感染小鼠的治疗效果。方法将80只小鼠随机等分为10组,每只小鼠经口感染8条裂头蚴;1~5组小鼠分别在感染后1、2、4、6和8周应用吡喹酮治疗(总剂量2 800mg/体重kg,3次/d,疗程3d),治疗后1周剖杀;6~9组小鼠均在感染后1周以相同剂量吡喹酮进行治疗,分别在治疗后2、4、6和8周剖杀;第10组小鼠仅灌服蒸馏水,感染后第9周剖杀。检获裂头蚴,计算各组平均检获虫数和减虫率。结果裂头蚴感染后1、2、4、6和8周,小鼠应用吡喹酮治疗1周(1~5组)的减虫率分别为39.00%、18.00%、17.13%、14.00%和8.38%(P<0.05);减虫率具有随感染后开始治疗时间的延迟而降低的趋势(P<0.05)。小鼠感染裂头蚴后1周,应用吡喹酮治疗后1、2、4、6和8周(1、6~9组)的减虫率分别为39.00%、29.63%、18.75%、14.00%和6.25%(P<0.05),减虫率具有随治疗后时间的延长而降低的趋势(P<0.05)。感染裂头蚴后1~8周小鼠应用吡喹酮治疗和感染1周后小鼠应用吡喹酮治疗1~8周,减虫率变化趋势一致,即随感染后时间的延长而降低。结论吡喹酮对小鼠裂头蚴感染无明显疗效。
Objective To further study the therapeutic effect of praziquantel on mice infected with sporozoite. Methods Eighty mice were randomly divided into 10 groups. Each mouse was orally infected with 8 spleniccodes. 1 to 5 mice were treated with praziquantel at 1, 2, 4, 6 and 8 weeks after infection The total dose of 800 mg / kg body weight, 3 times / d, treatment for 3d), 1 week after treatment; 6 to 9 mice were treated with the same dose of praziquantel 1 week after infection, respectively, after treatment 2 , Killed at 4, 6 and 8 weeks. Group 10 mice were drenched with distilled water only at the 9th week after infection. Cleft cercariae were seized, and the average number of seized worms and worm reduction rates were calculated. Results The worm reduction rates of mice treated with praziquantel at 1, 2, 4, 6 and 8 weeks after infection were 39.00%, 18.00%, 17.13%, 14.00% and 8.38% (P <0.05). The worm reduction rate decreased with the delay of starting treatment after infection (P <0.05). The worm reduction rates of 1, 2, 4, 6 and 8 weeks after treatment with praziquantel in groups 1, 6, and 9 were 39.00%, 29.63%, 18.75%, 14.00% 6.25% (P <0.05). The worm reduction rate decreased with the prolongation of treatment time (P <0.05). In mice treated with praziquantel and infected with praziquantel for 1 to 8 weeks after infection with 1 ~ 8 weeks after infection with the larvae, praziquantel treatment for 1 to 8 weeks showed a trend of change in the worm reduction rate, that is, decreased with time after infection. Conclusion Praziquantel has no significant effect on the infection of mice with.