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目的分析巨大型尖锐湿疣的临床及病理特征,为临床医生诊治本病提供参考。方法对2002年4月-2012年12月资料完整的17例巨大型尖锐湿疣临床特征、组织病理、治疗及预后进行分析。结果 17例巨大型尖锐湿疣主要发生在外阴、肛周等部位,外观呈球形、条索形、分叶状等不同形态,表面呈菜花状、乳头状,体积均超过核桃大小。女性患者12例,男性5例。病理表现典型,可见角化过度、角化不全、乳头瘤样增生、棘层肥厚、挖空细胞等基本特点。采用综合治疗,随访期间未见癌变病例。结论巨大型尖锐湿疣临床相对少见,目前对巨大型尖锐湿疣在诊断标准、病理性质、规范化诊疗、临床预后等方法缺乏共识,提高临床医生对本病的本质认识有重要意义。
Objective To analyze the clinical and pathological features of huge condyloma acuminatum and provide references for clinicians to diagnose and treat this disease. Methods The clinical features, histopathology, treatment and prognosis of 17 giant condyloma acuminatum, with complete data from April 2002 to December 2012, were analyzed. Results Seventeen cases of giant condyloma acuminatum mainly occurred in the vulva and anus and other parts. The appearance of the condyloma acuminatum was spherical, cord-shaped and lobulated. The surface of the genital warts was cauliflower-like and papilla-shaped with the volume exceeding the size of the walnut. Female patients in 12 cases, 5 males. Pathological manifestations, showing hyperkeratosis, keratosis, papillomatous hyperplasia, acanthosis, hollowing out the basic characteristics of cells. The use of comprehensive treatment, no cases of cancer during follow-up. Conclusions Huge condyloma acuminatum is relatively rare. At present, there is a lack of consensus on the diagnostic criteria, pathological features, standardized diagnosis and treatment, and clinical prognosis of giant condyloma acuminatum. It is of great significance to improve clinicians’ understanding of the nature of this disease.