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人口老龄化及其伴随的各种疾病已成为全球性健康问题,细胞外基质在老化过程中发生的变化及对机体产生的影响逐渐成为研究衰老的热点。在机体发育和衰老过程中,细胞外基质不仅可以为细胞提供结构支架、组织连接,调节实质细胞的形态、增殖、分化、代谢、迁移等生理活动,并且其本身组成成分、合成、代谢、重构等变化也会对机体各系统的功能产生深刻影响,具体表现为骨骼肌僵硬、左心室功能受损、神经突触传导抑制等。本文通过介绍机体在衰老过程中,运动、循环、神经等系统细胞外基质的变化及相关机制的最新研究进展,从非细胞角度探讨老化的机制,了解衰老的过程。
Population aging and its accompanying diseases have become global health problems. The changes of the extracellular matrix during aging and its impact on the body gradually become hot spots for the study of aging. In the process of body development and aging, the extracellular matrix can not only provide the structural support for the cells, organize the connection, regulate the morphological, proliferation, differentiation, metabolism, migration and other physiological activities of the cells, but also make up its own composition, synthesis, metabolism, Structural changes will also have a profound impact on the function of the body’s various systems, specifically for skeletal muscle stiffness, impaired left ventricular function, inhibition of nerve synaptic transmission. In this paper, we introduce the latest research progress of the changes of the extracellular matrix in the process of aging, such as movement, circulation and nervous system, and the related mechanisms. We will explore the mechanism of aging from an acellular perspective to understand the aging process.