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对缺血后心肌进行再灌注治疗是近代医学的一大进展,缺血再灌注损伤也日益引起人们高度的重视.心肌再灌注损伤多以四种形式出现:①再灌注可使缺血区存活的心肌和内皮细胞发生不可逆性坏死,这是再灌注损伤最重要的一种表现形式,可导致梗死面积的扩大.②尽管恢复血供,但缺血区发生无复流现象和冠脉血流储备减少,使缺血心肌并无或无充分的血液供应.③心肌顿抑使局部存活的心肌收缩功能暂时性减退或消失.④往往在短暂的(5～15min)冠脉缺血后、再灌注数秒到数分钟内出现
Reperfusion after myocardial ischemia is a major progress in modern medicine, ischemia-reperfusion injury is also increasingly aroused people’s attention.Myocardial reperfusion injury occurs in four forms: ① reperfusion can make ischemic survival Of myocardial and endothelial cells irreversibly necrotic, which is the most important manifestation of reperfusion injury, can lead to an expansion of the infarct size.② Despite the resumption of blood supply, but the no-reflow phenomenon occurred in the ischemic area and coronary blood flow Reserve reduced, so that no or insufficient blood supply to the ischemic myocardium.③study myocardial infarction temporary survival of myocardial contractile function temporarily reduced or disappeared.④ often in the short (5 ~ 15min) after coronary ischemia, and then Perfusion seconds to minutes appear