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目的:探讨足月胎膜早破产妇与新生儿感染的临床关系。方法:选择2014年3月-2016年12月期间本院收治的44例足月胎膜早破产妇作为观察组,另选择同期在本院分娩44例足月分娩未胎膜早破的正常产妇作为对照组。两组产妇入院后均行阴道分泌物培养和阴道分泌物样炎性介质检测,两组新生儿均行细菌筛查,比较两组产妇阴道分泌物培养结果和新生儿细菌筛查结果,并比较两组产妇白介素6(IL-6)及肿瘤坏死因子α(TNF—α)等炎性介质水平。结果:观察组产妇感染率(11.63%)显著高于对照组(2.27%),观察组新生儿感染率(9.09%)显著高于对照组(0),组间差异均显著p<0.05。观察组产妇IL-6[(528.74±97.48)ng/ml]、TNF—α[(13.05±3.74)μmol/ml]指标水平均显著高于对照组[(287.69±87.71)ng/ml、(8.47±1.26)μmol/ml],组间差异p<0.05。结论:足月胎膜早破产妇与新生儿感染风险均较大,应做好孕期阴道/宫颈感染预防,避免胎膜早破发生,保证母婴安全。
Objective: To investigate the clinical relationship between full-term premature rupture of membranes and neonatal infection. Methods: From March 2014 to December 2016, 44 cases of full-term premature rupture of membranes treated in our hospital were selected as the observation group. Another 44 cases of full-term premature rupture of membranes As a control group. Two groups of women were admitted to hospital after vaginal secretions culture and vaginal secretions like inflammatory mediators, both groups of newborns were screened for bacteria, vaginal secretions of the two groups were compared culture results and neonatal bacterial screening results, and compared Two groups of maternal interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) and other inflammatory mediators. Results: The infection rate (11.63%) in the observation group was significantly higher than that in the control group (2.27%). The neonatal infection rate (9.09%) in the observation group was significantly higher than that in the control group (0). The levels of IL-6 [(528.74 ± 97.48) ng / ml and TNF-α [13.05 ± 3.74 μmol / ml] in the observation group were significantly higher than those in the control group [(287.69 ± 87.71) ng / ml and ± 1.26) μmol / ml], the difference between groups was p <0.05. Conclusion: The risk of preterm premature rupture of membranes is high in maternal and newborn infants. Prevention of vaginal / cervical infection during pregnancy should be done to prevent the occurrence of premature rupture of membranes and to ensure the safety of mother and infant.