论文部分内容阅读
[目的]评价糖化血清白蛋白（G A ）作为反映近期（2周内）血糖控制总体水平的指标在糖尿病人群中的临床应用价值。[方法]收集本院住院的523例2型糖尿病（T2DM ）患者，测定空腹血糖（FPG ）、餐后2小时血糖（2hPG）、1日指尖血糖谱均值（MBG）、GA、糖化血红蛋白（HbA1c）等，并对其中132例住院近2周的患者分别在入院后d6及d12复查上述指标。[结果]①523例患者中，GA与 HbA1c（r＝0．792、）、FPG（r＝0．542）、2hPG（r＝0．457）、MBG（r＝0．402）均呈正相关（ P均＜0．01）。②132例住院近2周的T2DM 患者入院后d6 GA为（27．2±5．46）％、入院d12为（22．78±4．35）％，均显著低于入院d1的（30．32±6．76）％（ P ＜0．01）。③132例入院d6和d12的GA较入院d1分别下降3．12％和7．54％（均 P ＜0．01），平均降幅分别为10．2％和23．6％；HbA1c在入院后d6和d12分别下降0．31％和0．78％，平均降幅为2．58％和6．45％，GA的降幅显著大于 HbA1c（ P ＜0．01）。[结论]GA可以及时、准确的反映短期内（1～2周）平均血糖水平的变化，并与长期血糖控制的金标准 HbA1c有良好的相关性，是糖尿病患者血糖控制情况的良好监测指标。“,”[Objective]To evaluate the clinical value of glycated albumin (GA ) as the indicator to reflect glucose control level in patients with type 2 diabetes mellitus (T2DM ) in recent period (within 2 weeks) .[Methods] Totally 523 patients with T2DM in our hospital were collected .The fasting plasma glucose(FPG) , post-prandial plasma glucose(2hPG) ,one-day mean blood glucose(MBG) at finger tip ,GA and HbA1c were measured .The above parameters in 132 patients hospitalized for about 2 weeks on d6 and d12 after admission were measured again .[Results] Among 523 patients ,GA levels were positively correlated with HbA 1c(r=0 .792) ,FPG(r=0 .542) ,2hPG(r=0 .457) and MBG(r=0 .402)(all P <0 .01) .GA levels in 132 patients hospitalized for about 2 weeks on d6 and d12 after admission were (27 .2 ± 5 .46)% and (22 .78 ± 4 .35)% re-spectively ,which were significantly lower than those on d1 after admission[(30 .32 ± 6 .76)% ] ( P <0 .01) . Compared with d1 after admission ,GA levels in 132 patients on d6 and d12 after admission decreased by 3 .12%and 7 .54% respectively(all P<0 .01) ,and the average decreasing level was 10 .2% and 23 .6% ,respectively . HbA1c value on d6 and d12 after admission decreased by 0 .31% and 0 .78% respectively ,and the average de-creasing level was 2 .58% and 6 .45% respectively .The decreasing level of GA was significantly higher than that of HbA1c( P < 0 .01) .[Conclusion] GA can promptly and accurately reflect the change of mean blood glucose level in short time(1~2 weeks) ,and has good relation with the gold standard of HbAlc which reflects the long-term glucose control .Therefore ,it is a good indicator to monitor blood glucose control in patients di-abetes mellitus .