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利用放射免疫测定方法,探讨腹腔注射吗啡对单纯乌拉坦麻醉、心肌损伤和心外膜涂酸大鼠中枢亮氨酸脑啡肽(LEKIS)和β-内啡肽样免疫活性物质(β-EPIS)含量的影响.结果表明注射吗啡对单纯乌拉坦麻醉大鼠和心肌损伤大鼠中枢LEKIS和β-EPIS含量的影响不显著,但可使心外膜涂酸大鼠的下丘脑、丘脑、中脑、桥脑内的LEKIS含量明显减少(P<0.01);海马和延脑的LEKIS含量亦减少(P<0.05);β-EPIS的含量在垂体明显减少(P<0.01);延脑和其它脑区亦有下降趋势,但无统计学意义.提示:吗啡可使心外膜涂酸组大鼠中枢多个脑区的LEKIS以及垂体β-EPIS含量下降.
The radioimmunoassay was used to investigate the effects of morphine on the expression of LEKIS and β-EP in the myocardium and epicardium of rats exposed to pure urethane anesthesia, myocarditis and β-EPIS ) Content.The results showed that injection of morphine had no significant effect on LEKIS and β-EPIS content in the myocardium of rats with simple urethane anesthesia and myocardial injury, but it could make the hypothalamus, thalamus, The content of LEKIS in the brain and pontine decreased significantly (P <0.01), the content of LEKIS in hippocampus and extensor brain decreased (P <0.05), the content of β-EPIS in the pituitary decreased significantly (P <0.01) The brain area also showed a downward trend, but not statistically significant.Conclusion: Morphine can decrease the levels of LEKIS and pituitary β-EPIS in multiple brain regions in epicardial rats.