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目的观察安宫牛黄丸联合丙种球蛋白治疗重症手足口病的临床疗效。方法选取2012年10月—2013年10月我院收治的重症手足口病患儿96例,将其随机分为试验组50例和对照组46例。两组患儿均给予常规综合治疗,试验组在常规综合治疗基础上加用安宫牛黄丸联合丙种球蛋白治疗,对照组在常规综合治疗基础上仅给予丙种球蛋白治疗,比较两组患儿退热时间、疱疹消退时间、口腔炎愈合时间、神经受累时间、住院时间以及临床疗效。结果试验组患儿退热时间、疱疹消退时间、口腔炎愈合时间、神经受累时间及住院时间均短于对照组(P<0.05)。对照组总有效率为78.3%(36/46),低于试验组的96.0%(48/50)(P<0.05)。结论安宫牛黄丸联合丙种球蛋白治疗重症手足口病能够有效缩短患儿病程、退热时间及临床症状改善时间,疗效显著,具有较高的临床应用价值。
Objective To observe the clinical efficacy of Angong Niuhuang Wan combined with gamma globulin in the treatment of severe hand-foot-mouth disease. Methods Ninety-six children with severe HFMD admitted to our hospital from October 2012 to October 2013 were randomly divided into experimental group (n = 50) and control group (n = 46). The two groups of children were given conventional comprehensive treatment, the experimental group on the basis of conventional comprehensive treatment plus Angong Niuhuang Pill combined with gamma globulin, the control group on the basis of conventional comprehensive treatment only given gamma globulin treatment, the two groups of children Fever time, herpes subsided time, stomatitis healing time, nerve involvement time, hospital stay and clinical efficacy. Results The antipyretic time, herpes remission, stomatitis healing time, nerve involvement time and hospital stay in experimental group were shorter than those in control group (P <0.05). The total effective rate of the control group was 78.3% (36/46), which was lower than 96.0% (48/50) of the experimental group (P <0.05). Conclusions Angong Niuhuang Pills combined with gamma globulin in the treatment of severe hand-foot-mouth disease can effectively shorten the duration of the disease, the time of fever relief and the improvement of clinical symptoms, with significant curative effect and high clinical value.