目的探讨LKB1与腺癌的发生发展的关系。方法搜集整理1999-2009年国内外发表的相关文献,对LKB1结构功能、抑癌机理及其在不同腺癌组织中的表达情况进行总结分析,并对LKB1与腺癌发生、发展及转移之间的关系进行回顾性分析。结果LKB1的突变或缺失表达与众多腺癌的发生发展成正相关,如肺腺癌、乳腺癌和胃腺癌等。在肺腺癌的脑转移过程中,LKB1的缺失表达起积极作用。结论通过对LKB1基因的修复,可以增加腺癌细胞凋亡,从而为腺癌早期诊断及治疗提供新的思路和依据。 Objective To investigate the relationship between LKB1 and the development of adenocarcinoma. Methods To collect the relevant literatures published at home and abroad from 1999 to 2009, and to summarize the function and mechanism of LKB1 and the expression of LKB1 in different adenocarcinoma tissues. The relationship between LKB1 and occurrence, development and metastasis of adenocarcinoma The relationship between the retrospective analysis. Results The mutation or deletion of LKB1 was positively correlated with the occurrence and development of many adenocarcinomas such as lung adenocarcinoma, breast cancer and gastric adenocarcinoma. During the brain metastasis of lung adenocarcinoma, LKB1 deletion expression plays a positive role. Conclusion The repair of LKB1 gene can increase the apoptosis of adenocarcinoma cells and provide a new idea and basis for the early diagnosis and treatment of adenocarcinoma.