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Livin是凋亡抑制蛋白(IAPs)家族的新成员,含有一个BIR结构和一个RING结构,BIR结构为Livin抑制细胞凋亡所必需,而RING结构具有E3泛素连接酶活性,Livin具有凋亡抑制作用已经在很多实验观察和临床研究中得到证实,但也有研究发现在效应caspase-3/-7作用下也能生成具有促凋亡作用的tLivin;Smac是一种内源性线粒体促凋亡蛋白,Smac不诱导正常细胞的凋亡,在细胞受凋亡信号刺激后释放到胞质,特异的结合并抑制IAPs对凋亡下游效应caspases的抑制,从而促进细胞凋亡。二者在细胞内相互调控、相互制约。
Livin is a new member of the family of apoptosis inhibitors (IAPs), which contains a BIR structure and a RING structure. The BIR structure is necessary for Livin to inhibit apoptosis. The RING structure has E3 ubiquitin ligase activity, and Livin has apoptosis inhibition It has been confirmed in many experimental observations and clinical studies. However, some studies have found that tLivin can also induce apoptosis in response to caspase-3 / -7. Smac is an endogenous mitochondrial proapoptotic protein , Smac does not induce apoptosis in normal cells, and is released into the cytoplasm when cells are stimulated by apoptotic signals. Specifically, Smac inhibits IAPs’ inhibition of caspases downstream of apoptosis and promotes apoptosis. Both in the cell mutual regulation, mutual restraint.