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目的：比较生脉注射液（ＩＳＭ）与西地兰（ＤＳＮＳ）对阿霉素（ＡＤＲ）引起心脏损伤的保护作用。方法：以ＡＤＲ处理Ｗｉｓｔａｒ大鼠造成心脏损伤模型，同时ｉｐＩＳＭ、ＤＳＮＳ，到期测血中ＳＧＯＴ、ＬＤＨ及同功酶、ＨＢＤＨ、ＳＯＤ、ＭＤＡ并进行心肌病理检查。结果：ＩＳＭ、ＤＳＮＳ组与ＡＤＲ组相比，血中ＳＯＤ升高，ＭＤＡ降低。ＩＳＭ组ＳＧＯＴ、ＬＤＨ、ＨＢＤＨ及ＬＤＨ１／ＬＤＨ２比值降低，心肌病理计分下降。ＤＳＮＳ组除ＬＤＨ１／ＬＤＨ２比值降低外，血中ＳＧＯＴ、ＬＤＨ、ＨＢＤＨ无显著性差异，心肌病理检查提示轻度保护作用，但无统计学意义。结论：生脉注射液对阿霉素引起心脏损伤的保护作用优于西地兰
Objective: To compare the protective effects of Shengmai Injection (ISM) and cedilanid (DSNS) on adriamycin-induced cardiac injury. Methods: Wistar rats were treated with ADR to establish a model of heart injury. At the same time, ipISM, DSNS, SGOT, LDH and isozymes, HBDH, SOD and MDA in expired blood were measured and pathological examination was performed. Results: Compared with ADR group, the levels of SOD and MDA in ISM and DSNS groups were significantly lower than those in ADR group. The ratio of SGOT, LDH, HBDH and LDH1 / LDH2 in ISM group decreased, and the score of myocardial pathology decreased. In addition to the reduction of LDH1 / LDH2 ratio in DSNS group, there was no significant difference in SGOT, LDH and HBDH in blood, and myocardial pathological examination showed mild protective effect, but there was no statistical significance. Conclusion: Shengmai Injection has a better protective effect on doxorubicin-induced heart injury than cedilanid