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探讨中国苏皖地区汉族急性心肌梗塞患者C反应蛋白(CRP)基因启动子T-757C多态性。方法以160例AMI患者(AMI组)和182例非冠心病者(对照组)作为研究对象,应用聚合酶链反应-限制性片段长度多态性方法检测CRP基因T-757C多态性。结果与对照组相比,AMI组的TC基因型频率明显增高(31.2%∶41.3%,P<0.05),TT和CC基因型以及T等位基因频率分布差异无统计学意义(P>0.05)。在调整冠心病相关危险因素并经多元logistic回归分析显示,CRP基因T-757C多态性TC基因型与AMI的发生仍呈显著性相关(OR=1.650,95%CI:1.031～2.640,P<0.05)。结论在中国苏皖地区汉族人群中,CRP基因启动子T-757C多态性与AMI的发病相关。
To investigate the T-757C polymorphism of C-reactive protein (CRP) gene promoter in patients with acute myocardial infarction in Jiangsu and Anhui Provinces. Methods T-757C polymorphism of CRP gene was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 160 patients with AMI (AMI group) and 182 patients with non-coronary heart disease (control group). Results Compared with the control group, the frequencies of TC genotypes in AMI group were significantly higher than those in control group (31.2% vs 41.3%, P <0.05). There was no significant difference in the frequencies of TT and CC genotypes and T allele (P> 0.05) . In multivariate logistic regression analysis, the risk factors of coronary heart disease were adjusted and the genotypes of T-757C polymorphism of CRP gene were still significantly correlated with AMI (OR = 1.650, 95% CI: 1.031-2.640, P < 0.05). Conclusion The polymorphism of T-757C in CRP gene is associated with the pathogenesis of AMI in Han population of Jiangsu and Anhui provinces.