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1938年Hallpike和Cairns首次描述了美尼尔氏病内淋巴囊积水和内淋巴囊周围纤维变性的病理改变。本文介绍5例美尼尔氏病的病史和组织病理学所见,并对每例在行硬脑膜外引流时所得到的内淋巴囊标本进行了电子显微镜观察。结果:5个内淋巴囊标本中,只有一个看到有保存完好的上皮细胞。手术标本上难于看到上皮细胞是由于外科洛疗时上皮细胞容易从基底膜上分离所致。这一结论经电子显微照相得到证实。在内淋巴囊的腔内可看到漂浮的细胞核。由于上皮下纤维变性,基底膜和上皮细胞之间连接变弱,故上皮细胞更易从基底膜上分离。这些上皮细胞在电子显微照片上同正常上皮细胞比较可发现某些不寻常之处。即能看到有几个微小绒毛,某些包涵体和大量空泡。可以认为美尼尔氏病和少而小的微小绒毛之间有一定联系。但包涵
In 1938, Hallpike and Cairns first described the pathological changes of lymphocytic hydrops and fibrosis around the endolymphatic sac in Meniere’s disease. This article describes the history of 5 cases of Meniere’s disease and histopathology seen, and each case in the line of duodenal drainage obtained when the endolymphatic sac specimens were observed by electron microscopy. RESULTS: Of the five endolymphatic sac specimens, only one of the five well-preserved epithelial cells were seen. Difficult to see the epithelial cells on the surgical specimens is due to surgical treatment of epithelial cells easily separated from the basement membrane. This conclusion is confirmed by electron micrographs. Floating nuclei can be seen in the cavity of the endolymphatic sac. Due to sub-epithelial fibrosis, the connection between the basilar membrane and the epithelial cells is weakened, so the epithelial cells are more easily separated from the basal membrane. These epithelial cells in the electron micrographs compared with normal epithelial cells found some unusual. That is, you can see a few tiny villi, some inclusion bodies and a lot of vacuoles. There may be a link between Meniere’s disease and small but small hair. But inclusive