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目的观察胃窦肌间神经丛一氧化氮合酶(NOS)阳性神经元变化与重症急性胰腺炎(SAP)的关系。方法 SD大鼠采用逆行胰胆管注射5%牛磺胆酸钠方法制作SAP模型,进行胃排空率测定及双重免疫荧光染色法对胃窦肌间神经丛进行染色及计数,并对胰腺进行评分。结果 SAP大鼠胃排空率减低(P<0.01),胃窦肌间神经丛NOS阳性神经元数目增多(P<0.05)。结论 SAP大鼠胃窦肌间神经丛NOS阳性神经元增多,推测胃窦肌间神经丛NOS阳性神经元参与了肠神经系统的重塑。
Objective To investigate the relationship between the changes of nitric oxide synthase (NOS) positive neurons in the myenteric plexus of the antrum and severe acute pancreatitis (SAP). Methods SD rats were injected SAP with 5% sodium taurocholate by means of retrograde cholangiopancreatography. The gastric emptying rate and double immunofluorescence staining were used to stain and count the myenteric plexus of the antrum, and the pancreas was scored . Results The gastric emptying rate of SAP rats decreased (P <0.01), and the number of NOS positive neurons in gastric myenteric plexus increased (P <0.05). Conclusions NOS positive neurons in myenteric plexus of SAP rats increase. It is speculated that NOS positive neurons of myenteric plexus in the gastric antrum participate in the remodeling of the enteric nervous system.