论文部分内容阅读
目的探讨尿微量白蛋白(UMA)和血清胱抑素C(Cys-C)、β2-微球蛋白(β2-MG)、肌酐(SCr)、尿素(Urea)对糖尿病(DM)患者早期肾损伤的诊断价值。方法对120例糖尿病确诊患者[分为蛋白阳性组(78例)和蛋白阴性组(42例)]以及80例健康体检者(对照组)行上述五项指标测定,对检测结果进行对比分析。结果蛋白阳性组和蛋白阴性组UMA及血清Cys-C、β2-MG、SCr、Urea测定结果高于对照组(P<0.01或P<0.05),蛋白阳性组测定结果高于蛋白阴性组(P<0.05);随着患者组病情进展,UMA、Cys-C、β2-MG的检测价值明显高于SCr、Urea。结论 UMA及血清Cys-C、β2-MG、SCr、Urea等对早期诊断糖尿病肾病有不同的诊断价值,医生应根据临床需要合理申请,既减轻患者看病负担,又节约医院开支。
Objective To investigate the effects of urinary microalbuminuria (UMA) and serum cystatin C (Cys-C), β2-microglobulin (β2-MG), creatinine (SCr) and urea on diabetic nephropathy The diagnostic value. Methods 120 patients diagnosed with diabetes (divided into protein-positive group (78 cases) and protein-negative group (42 cases]) and 80 healthy subjects (control group) were measured by the above five indicators, and the test results were compared and analyzed. Results The results of UMA, Cys-C, β2-MG, SCr and Urea in protein-positive group and protein-negative group were higher than those in control group (P <0.01 or P < <0.05). The detection value of UMA, Cys-C and β2-MG was significantly higher than that of SCr and Urea with the progression of patients. Conclusions UMA, serum Cys-C, β2-MG, SCr and Urea have different diagnostic value for early diagnosis of diabetic nephropathy. Doctors should apply rationally according to clinical needs, which not only reduce the burden on patients but also save hospital expenses.