目的:观察参芪扶正注射液对结肠癌患者行术后辅助化疗的免疫功能影响。方法:将120例III期结肠癌术后患者随机分为两组,治疗组60个人行术后辅助化疗+参芪扶正针+对症支持治疗,对照组60个人行术后辅助化疗+对症支持治疗,6个疗程以后比较两组患者免疫功能的变化,用T细胞亚群的变化来对两组进行比较,通过对治疗组与对照组化疗前后CD4、CD4/CD8及NK细胞活性的变化来评估参芪扶正注射液对大肠癌术后化疗患者的免疫功能影响。结果 :治疗组化疗后CD4细胞、CD4/CD8、NK细胞活性明显增高(P<0.05),而对照组化疗后CD4细胞、CD4/CD8、NK细胞活性明显降低(P<0.05)。结论:参芪扶正注射液通过益气扶正的方法能增加结肠癌患者化疗耐受性,提高患者的免疫功能,是结肠癌患者术后行化疗合适的辅助用药。 Objective: To observe the effect of Shenqi Fuzheng injection on the immune function of postoperative adjuvant chemotherapy in patients with colon cancer. Methods: A total of 120 patients with stage III colon cancer were randomly divided into two groups. 60 patients in the treatment group received postoperative adjuvant chemotherapy plus Shenqifuzhengzhen + symptomatic supportive therapy, and 60 patients in the control group received postoperative adjuvant chemotherapy plus symptomatic supportive therapy The changes of immune function in the two groups were compared after 6 courses of treatment. The changes of T cell subsets were compared with those of the two groups, and the changes of CD4, CD4 / CD8 and NK cell activity before and after chemotherapy were evaluated in the treatment group and the control group Effect of Shenqi Fuzheng Injection on Immune Function in Patients with Colorectal Cancer After Chemotherapy. Results: The activity of CD4, CD4 / CD8 and NK cells in the treatment group was significantly increased after chemotherapy (P <0.05), while the activity of CD4, CD4 / CD8 and NK cells in the control group was significantly decreased after chemotherapy (P <0.05). Conclusion: Shenqi Fuzheng injection through the method of Qi and right can increase chemotherapy in patients with colon cancer tolerance and improve immune function in patients with colon cancer is the appropriate adjuvant chemotherapy.