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为了延长尿激酶原的半衰期，采用聚乙二醇５０００（ＰＥＧ５０００）对该酶进行了修饰。结果表明，尿激酶原经ＰＥＧ修饰后，在兔体内的半衰期延长了９～１３倍，同时酶活性也有损失，溶酰胺活性保持６２％，溶纤活性保持３．８％～１０％。
To prolong the half-life of pro-urokinase, the enzyme was modified with polyethylene glycol 5000 (PEG5000). The results showed that the half-life of urokinase in PEG was 9-13 fold longer than that in the rabbit, and the enzyme activity was also lost. The activity of soluble amide was 62% and that of soluble fiber was 3.8% -10%.