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目的 :探讨人乳头瘤病毒 16 E7蛋白 (HPV16 E7)与宫颈癌间的关系。方法 :采用免疫组化 SP法对 15例正常宫颈组织、 80例宫颈鳞癌、 17例腺癌组织进行了研究。结果 :1HPV16 E7蛋白在宫颈癌中的表达明显高于正常宫颈组织 ,且在鳞癌中的表达明显高于腺癌 ;2 HPV16 E7蛋白表达与宫颈癌的临床分期成负相关 ,与组织学分级、淋巴结转移无关。结论 :预防 HPV感染是防止宫颈癌发生的重要措施之一。
Objective: To investigate the relationship between human papillomavirus 16 E7 protein (HPV16 E7) and cervical cancer. Methods: 15 cases of normal cervical tissue, 80 cases of cervical squamous cell carcinoma and 17 cases of adenocarcinoma were studied by immunohistochemical SP method. Results: The expression of 1HPV16 E7 protein in cervical cancer was significantly higher than that in normal cervical tissue, and it was significantly higher in squamous cell carcinoma than in adenocarcinoma. 2 The expression of HPV16 E7 protein was negatively correlated with the clinical stage of cervical cancer, , Lymph node metastasis has nothing to do. Conclusion: Prevention of HPV infection is one of the important measures to prevent cervical cancer.