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目的探讨丙型肝炎病毒核心抗原(HCV-cAg)、抗体(HCV-Ab)与丙肝病毒RNA(HCV-RNA)之间的关系。方法对150例丙型肝炎(简称丙肝)抗体阳性感染者和100例健康体检者,分别进行HCV-cAg、HCV-Ab和HCV-RNA检测,对其相关性进行分析。结果 150例HCV-Ab阳性感染者中,HCV-cAg和HCV-RNA的阳性率分别为40%和42%。100例健康体检者中,HCV-Ab均为阴性,但有2例HCV-cAg阳性,阳性率为2%,此2例经HCV-RNA检测,均确诊为阳性。结论 HCV-cAg和HCV-RNA几乎同时出现,均能较准确的反映HCV复制状态。但由于HCV-cAg检测敏感性及特异性好、费用低、操作方便,对丙型感染病毒感染的辅助诊断具有重要意义。
Objective To investigate the relationship between hepatitis C virus core antigen (HCV-cAg), antibody (HCV-Ab) and hepatitis C virus RNA (HCV-RNA). Methods 150 cases of hepatitis C (HCV) positive patients and 100 healthy subjects were tested for HCV-cAg, HCV-Ab and HCV-RNA, and their correlations were analyzed. Results The positive rates of HCV-cAg and HCV-RNA in 150 HCV-Ab positive patients were 40% and 42% respectively. Among 100 healthy subjects, HCV-Ab was negative, but 2 of them were positive for HCV-cAg, the positive rate was 2%. Both of them were confirmed by HCV-RNA. Conclusions HCV-cAg and HCV-RNA occur almost simultaneously, which can reflect HCV replication status more accurately. However, due to the sensitivity and specificity of HCV-cAg detection, low cost and convenient operation, it is of great significance for the auxiliary diagnosis of HCV infection.