多发性硬化是中枢神经系统一种广泛脱髓鞘性自身免疫性疾病,其发病机制与免疫调节功能异常密切相关。一氧化氮具有重要的免疫调节作用,它与多发性硬化的发生、发展有着密切的关系。一氧化氮在多发性硬化的经典动物模型—实验性变态反应性脑脊髓炎的预防和治疗中发挥重要作用。因此,对一氧化氮的深入研究将为临床防治多发性硬化等自身免疫疾病提供有价值的新思路。 Multiple sclerosis is a broad demyelinating autoimmune disease of the central nervous system and its pathogenesis is closely related to abnormal immune regulation. Nitric oxide has an important immunomodulatory effect, which is closely related to the occurrence and development of multiple sclerosis. Nitric oxide plays an important role in the prevention and treatment of experimental allergic encephalomyelitis, a classic animal model of multiple sclerosis. Therefore, in-depth study of nitric oxide will provide valuable new ideas for clinical prevention and treatment of multiple sclerosis and other autoimmune diseases.