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目的:观察中医辨证联合西药治疗女性高泌乳素血症的临床疗效。方法:将83例患者随机分为2组,对照组41例应用甲磺酸溴隐亭片治疗,观察组42例在对照组基础上联合中医辨证用药,比较2组治疗前后血清催乳素(PRL)水平、治疗总有效率及不良反应发生率。结果:观察组总有效率为90.8%(38/42),对照组为68.3%(28/41),2组比较,差异有统计学意义(P<0.05)。治疗前,2组血清PRL水平的差异无统计学差异(P>0.05);治疗1月、2月、3月后,2组PRL水平均降低,组内前后差异有统计学意义(P<0.05);且观察组1月、2月、3月时的血清PRL水平均低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为11.9%(5/42),对照组为9.8%(4/41),2组比较,差异无统计学意义(P>0.05)。结论:中医辨证联合西药治疗女性高泌乳素血症效果显著,安全性高。
Objective: To observe the clinical effect of traditional Chinese medicine combined with western medicine on female hyperprolactinemia. Methods: 83 patients were randomly divided into two groups, the control group, 41 cases were treated with bromocriptine mesylate tablets, the observation group of 42 patients on the basis of the control group combined with traditional Chinese medicine, compared prolactin (PRL ) Level, the total effective rate of treatment and the incidence of adverse reactions. Results: The total effective rate was 90.8% (38/42) in the observation group and 68.3% (28/41) in the control group. There was significant difference between the two groups (P <0.05). Before treatment, there was no significant difference in serum PRL levels between the two groups (P> 0.05). After 1 month, 2 months and 3 months of treatment, the PRL levels of both groups were decreased, with significant difference before and after treatment (P <0.05 ). The levels of serum PRL in the observation group at January, February and March were lower than those in the control group (P <0.05). Adverse reactions in the observation group were 11.9% (5/42) in the observation group and 9.8% (4/41) in the control group. There was no significant difference between the two groups (P> 0.05). Conclusion: TCM syndrome differentiation combined with western medicine treatment of female hyperprolactinemia effect is significant, safe.