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内皮抑素(endostatin,ES)是一种能特异性作用于内皮细胞,并能抑制血管生成的内源性血管生长调节因子。自1997年美国哈佛大学O’Reilly从鼠血管内皮细胞瘤株的培养液中分离出内皮抑素,经纯化和氨基酸测序后,发现它是胶原蛋白的ⅩⅤⅢ的一个片段,并证实它是一种潜在的内源性抗血管新生因子。经多个实验证实,ES能有效抑制多达60种以上不同种类肿瘤,并能调节12%的人类基因组表达,从而下调病理性血管发生而没有毒副作用,也无耐药性,是
Endostatin (ES) is an endogenous angiogenesis regulatory factor that acts specifically on endothelial cells and inhibits angiogenesis. Since endostatin was isolated from the culture of murine vascular endothelial cell strains by O’Reilly, Harvard University in 1997, purified and amino acid sequenced, it was found to be a fragment of collagen XVIII and confirmed to be a Potential Endogenous Antiangiogenic Factor. After several experiments confirmed that ES can effectively inhibit up to more than 60 different types of tumors and can regulate 12% of the human genome expression, thereby reducing pathological angiogenesis without toxic side effects, there is no resistance, is