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目的探讨老年戊型肝炎患者血清ＮＯ、ＭＤＡ、ＳＯＤ与发病的关系。方法采用Ｇｒｉｅｒｓ比色法测定ＮＯ，以ＴＢＡ法测定ＭＤＡ，以分光光度法测定ＳＯＤ。结果老年戊型肝炎患者血清ＮＯ、ＭＤＡ浓度明显高于正常老年对照组（Ｐ＜０．０５），ＳＯＤ明显低于正常老年对照组（Ｐ＜０．０５）。血清胆红素＞８５．５ｎｍｏｌ／Ｌ者与＜８５．５ｎｍｏｌ／Ｌ者血清ＮＯ之间差异无显著性，而血清ＭＤＡ、ＳＯＤ差异有显著性（Ｐ＜０．０５～０．０１）。发生重型肝炎者与未发生重型肝炎者血清ＮＯ、ＭＤＡ、ＳＯＤ均有显著性差异（Ｐ＜０．０５～０．０１）。血清ＮＯ浓度与ＭＤＡ呈负相关（Ｐ＜０．０５），与ＳＯＤ呈正相关（Ｐ＜０．０１），ＳＯＤ浓度与血清ＳＯＤ浓度亦呈负相关（Ｐ＜０．０５）。结论老年成型肝炎患者存在着严重的氧化剂及抗氧化剂失衡状态，脂质过氧化程度及受自由基攻击的程度均较深。ＮＯ、ＭＤＡ、ＳＯＤ失衡在老年成型重型肝炎发病中起一定作用，ＭＤＡ、ＳＯＤ可作为判定老年成型肝炎病情及预后的一种指标。
Objective To investigate the relationship between serum NO, MDA, SOD and the incidence of hepatitis E in elderly patients. Methods Griers colorimetry was used to determine NO, TBA method was used to determine MDA, and SOD was determined by spectrophotometry. Results The levels of serum NO and MDA in elderly patients with hepatitis E were significantly higher than those in the control group (P <0.05), and the levels of SOD were significantly lower than those in the control group (P <0.05). Serum bilirubin> 85.5nmol / L and <85.5nmol / L of serum NO was no significant difference between the serum MDA, SOD difference was significant (P <0.05 ~ 0.01). Serum NO, MDA and SOD were significantly different between patients with and without severe hepatitis (P <0.05 ~ 0.01). Serum NO concentration was negatively correlated with MDA (P <0.05), positively correlated with SOD (P <0.01), and SOD concentration was negatively correlated with serum SOD concentration (P <0.05). Conclusion There is a serious imbalance of oxidants and antioxidants in elderly patients with hepatitis. The degree of lipid peroxidation and the extent of attack by free radicals are deep. The imbalance of NO, MDA and SOD plays an important role in the pathogenesis of severe hepatitis in the elderly, and MDA and SOD may be used as indicators to determine the severity and prognosis of senile hepatitis.