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目的 研究尿毒症维持性血液透析 (血透 )患者血浆瘦素水平及其与营养状态的关系。方法 选择维持性血透患者及健康人各 30例 ,于空腹取血 ,应用放射免疫分析法测定血浆中瘦素水平 ;同时检测肾功能、血浆白蛋白、转铁蛋白、前白蛋白和胰岛素水平等。结果 血透患者的血浆瘦素浓度明显高于正常对照组 (P <0 0 1) ;血浆白蛋白、转铁蛋白及前白蛋白含量两组间差异均有显著性(P <0 0 1)。血透组患者血浆瘦素浓度与体重指数 (BMI,体重 /身高2 )、肱三头肌皮褶厚度 (TSF)和胰岛素水平呈明显正相关 (r值分别为 0 5 3、0 6 6、0 5 7,P <0 0 1) ,而与血尿素氮 (BUN)、肌酐 (Scr)、甘油三脂 (TG)、总胆固醇、高密度脂蛋白、低密度脂蛋白、白蛋白、转铁蛋白、前白蛋白、标准化蛋白分解率等则无明显相关关系。结论 尿毒症维持性血透患者血浆瘦素浓度明显升高 ,其浓度与BMI、TSF及胰岛素水平呈正相关 ,未发现瘦素浓度与常用的评价营养指标、尿素氮、血肌酐和血脂有相关关系
Objective To study the relationship between plasma leptin levels and nutritional status in maintenance hemodialysis (hemodialysis) patients with uremia. Methods Thirty patients with maintenance hemodialysis and healthy volunteers were selected and fasting blood was collected. Plasma leptin level was measured by radioimmunoassay. Meanwhile, renal function, serum albumin, transferrin, prealbumin and insulin levels Wait. Results The plasma leptin concentration in hemodialysis patients was significantly higher than that in the normal control group (P <0.01). There were significant differences in plasma albumin, transferrin and prealbumin levels between the two groups (P <0.01) . Serum leptin concentrations in patients with hemodialysis were positively correlated with body mass index (BMI, body weight / height 2), triceps skinfold fold (TSF), and insulin (r values were 0 5 3, 06 6, (P <0.01), but not with BUN, Scr, TG, total cholesterol, HDL, LDL, albumin, iron transfer Protein, prealbumin, normalized protein decomposition rate, etc. There is no obvious correlation. Conclusions Plasma leptin concentrations in patients with maintenance hemodialysis were significantly increased, and the concentrations were positively correlated with BMI, TSF and insulin levels. There was no correlation between leptin levels and commonly used nutritional indexes, urea nitrogen, serum creatinine and blood lipids