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目的探讨脑电双频谱指数(BIS)指导丙泊酚靶控静脉输注用于小儿腹腔镜手术对血流动力学的影响。方法 168例行腹腔镜手术患儿,随机分为观察组(实施BIS指导丙泊酚靶控静脉输注)与对照组(静脉注射丙泊酚实施全身麻醉),各84例。观察麻醉效果。结果观察组手术拔管后平均动脉压(MAP)为(10.43±0.31)k Pa、血氧饱和度(Sp O2)为(96.13±0.84)%、心率(HR)为(105.33±12.75)次/min、丙泊酚用量为(1.21±0.43)mg/kg、苏醒时间为(3.27±0.11)min、不良反应发生率为2.38%,均显著优于对照组的(12.94±0.47)k Pa、(97.69±0.17)%、(117.54±14.37)次/min、(1.79±0.86)mg/kg、(6.84±0.25)min、10.71%,差异均具有统计学意义(P<0.05)。结论 BIS指导丙泊酚靶控静脉输注效果确切,可有效改善患儿血流动力学指标,且患儿苏醒更快,不良反应更少,具有较高的安全性,可在临床广泛推广。
Objective To investigate the effects of propofol target-controlled intravenous infusion (BIS) guided by BIS on hemodynamics in pediatric laparoscopic surgery. Methods 168 children undergoing laparoscopic surgery were randomly divided into observation group (BIS-guided propofol target-controlled intravenous infusion) and control group (intravenous propofol for general anesthesia), 84 cases in each group. Observe the effect of anesthesia. Results The mean arterial pressure (MAP) of the observation group after extubation was (10.43 ± 0.31) kPa, the blood oxygen saturation (Sp O2) was (96.13 ± 0.84)% and the heart rate was (105.33 ± 12.75) (1.21 ± 0.43) mg / kg, the recovery time was (3.27 ± 0.11) min and the incidence of adverse reactions was 2.38%, which was significantly better than that of the control group (12.94 ± 0.47) kPa, ( 97.69 ± 0.17)%, (117.54 ± 14.37) /min, (1.79 ± 0.86) mg / kg, (6.84 ± 0.25) min, and10.71% respectively. The differences were statistically significant (P <0.05). Conclusion BIS instructed propofol target-controlled intravenous infusion of effective, can effectively improve children with hemodynamic indicators, and children wake up faster, fewer adverse reactions, with higher safety, can be widely promoted in the clinic.