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目的了解2005年中国3个县儿童人肠道病毒71型(Human Enterovirus 71,HEV71)抗体水平及HEV71在儿童中的自然感染状况,为预防控制手足口病(Hand-foot-mouth Disease,HFMD)在儿童中的流行提供依据。方法利用2005年9月进行儿童麻疹抗体水平调查时,在3个省各1个县共371名1～6岁儿童中所采集的血清标本,使用中和试验检测血清HEV71中和抗体,并对检测结果进行统计学分析。结果儿童HEV71中和抗体阳性164人,阳性率为44.2%。抗体阳性率分布与儿童年龄和所在地区有关,1岁儿童抗体阳性率最低,随着年龄的增长,抗体阳性率升高,各年龄抗体阳性率差异有显著的统计学意义(x2=25.73,P<0.05)。3个县儿童HEV71中和抗体阳性率不同,但差异无显著的统计学意义(x2=0.11,P>0.05)。抗体几何平均滴度1岁较低,2、3岁升高,4～6岁下降。3个县儿童HEV71中和抗体水平构成一致,以抗体阴性或低抗体水平为主。结论2005年以前3个县儿童曾发生HEV71感染;1～6岁儿童尤其是≤3岁儿童,HEV71中和抗体阳性率低,是HEV71导致HFMD的易感人群,应加强预防由HEV71引起的HFMD在≤3岁儿童中的流行或传播。
Objective To understand the antibody levels of human enterovirus 71 (HEV71) and the natural infection of HEV71 in children in three counties of China in 2005. To prevent and control hand-foot-mouth disease (HFMD) Provide a basis for the prevalence in children. Methods Serum samples collected from 371 children aged 1-6 years old in one county in three provinces during the survey of measles antibody levels of children in September 2005 were used to detect the neutralizing antibodies of HEV71 in the neutralization test Test results for statistical analysis. Results The positive rate of HEV71 neutralizing antibody in children was 164, with a positive rate of 44.2%. The distribution of antibody positive rate was related to the age of the child and the region. The positive rate of antibody in 1 year old children was the lowest. With the increase of age, the positive rate of antibody increased, the positive rate of antibody in each age had significant statistical significance (x2 = 25.73, P <0.05). The positive rate of HEV71 neutralizing antibody in 3 counties was different, but the difference was not statistically significant (x2 = 0.11, P> 0.05). Antibody geometric mean titer 1 year old lower, 2,3-year-old, 4 to 6 years of decline. The levels of neutralizing antibodies in HEV71 in three counties were consistent, with antibody negative or low antibody level as the main. CONCLUSIONS: HEV71 infection occurred in children in three counties before 2005. The positive rate of HEV71 neutralizing antibody in children aged 1 to 6 years, especially those ≤3 years of age, is a predisposing population for HEV71-induced HFMD. Prevention of HEV71-induced HFMD Prevalence or transmission in children ≤ 3 years old.