OBJECTIVE:To prospectively study the accuracy of the palliative prognostic index (PPI) survival predic-tion model combined with Traditional Chinese Medicine (TCM) syndrome differentiation.METHODS:The PPI survival prediction model was used to predict survival time.Patients\' real survival time was recorded.The survival.time was calculat-ed using the Kaplan-Meier method,and the log-rank method was used to test the difference.RESULTS:The average PPI survival prediction score of 227 patients was 5.83 (95％ CI:5.29-6.37).There was a significant difference in the real-life period between the different PPI groups (P ＜ 0.05).PPI group Ⅰ (predicted survival of ＞ 6 weeks) showed the highest predictive sensitivity and PPI group Ⅱ(predicted survival of 3-6 weeks) showed the high-est predictive specificity.According to TCM syn-drome differentiation,82 cases (36％) were diag-nosed with liver and kidney Yin deficiency (typeⅣ).The actual survival time of type Ⅳ patients was significantly shorter than that of other types of pa-tients (mean:21.85 vs 28.70,P=0.007).In group Ⅰ,the median survival time of type Ⅳ patients and other types was 25 and 34 d,respectively (P ＜0.001).The sensitivity and specificity of PPI predic-tion were improved in group Ⅱ by TCM syndrome differentiation.For patients in group Ⅲ whose pre-dicted survival time was ＜ 3 weeks,the specificity of PPI survival prediction was higher in type Ⅳpatients.CONCLUSION:This study shows that the PPI pre-dictive tool for survival rate has important value.TCM syndrome differentiation and typing has cer-tain significance for further classification and surviv-al prediction.