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目的通过对新生儿缺氧缺血性脑病(HIE)的病例治疗分析来探讨HIE的治疗方法,做到早治疗、早干预,以免造成神经系统不可逆损害。方法对该院儿科近3年来收治的HIE141例患儿,随机入选4组,各组在综合治疗的基础上应用不同的特殊药物治疗,并测定神经系统后遗症发生情况、智商发育商数。结果有效率:对照组为61.1%,纳洛酮组为91.4%,胞二磷胆碱组为88.6%,脑活素组为94.3%。3个治疗组之间比较,差异无统计学意义(P>0.05)。住院天数治疗组均短于对照组,差异有统计学意义(P<0.01),而3个治疗组之间比较,差异无统计学意义(P>0.05)。三治疗组智商发育商数与对照组的差异有统计学意义(P<0.01)。结论HIE患儿在传统综合治疗的基础上只要选择一组特殊药物,给予有效全程使用即可达到较好疗效。
Objective To investigate the treatment of HIE by analyzing the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Early treatment and early intervention are needed to avoid irreversible damage to the nervous system. Methods A total of 141 children with HIE admitted to our hospital during the past 3 years were enrolled in this study. All the patients were treated with different special drugs on the basis of comprehensive treatment. The occurrence of nervous system sequela and IQ quotient were determined. Results The effective rate was 61.1% in the control group, 91.4% in the naloxone group, 88.6% in the citicoline group and 94.3% in the cerebrolysin group. There was no significant difference between the three treatment groups (P> 0.05). The days of hospitalization in the treatment group were shorter than those in the control group, with significant difference (P <0.01). There was no significant difference between the three treatment groups (P> 0.05). Three treatment group IQ quotient and control group differences were statistically significant (P <0.01). Conclusion HIE children on the basis of the traditional comprehensive treatment as long as the choice of a group of special drugs, effective and full use can be achieved to achieve better results.