以脑血流、脑血管阻力、脑灌注压和颅内压为主要指标，测定家兔不同硫喷妥钠血药浓度下，上述指标的变化，以评价硫喷妥钠对颅内血流动力学影响。结果表明：在硫喷妥钠血药浓度较低时（≤３６．５ｍｍｏｌ／Ｌ），颅内压降低幅度大于脑灌注压和脑血流的下降幅度，有利于脑组织的血液灌注；硫喷妥钠血药浓度较高时（≥４８．５９ｍｍｏｌ／Ｌ），虽然有较强降低颅内压的作用，但其降低脑灌注压、脑血流的作用亦较明显，不利于脑组织的血液灌注。 To cerebral blood flow, cerebral vascular resistance, cerebral perfusion pressure and intracranial pressure as the main indicators, determination of different concentrations of thiopental in rabbits plasma concentrations of these indicators to evaluate the effect of thiopental on intracranial hemodynamic Learning impact. The results showed that when the plasma concentration of thiopental sodium was low (≤36.5mmol / L), the decrease of intracranial pressure was greater than that of cerebral perfusion pressure and cerebral blood flow, which was in favor of blood perfusion of brain tissue. When the plasma sodium concentration is higher (≥48.59mmol / L), the effect of decreasing cerebral perfusion pressure and cerebral blood flow is obvious, which is unfavorable to the blood of brain tissue perfusion.