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本文报道采用三尖杉酯碱联合化疗方案(HOP方案)治疗急性早幼粒细胞白血病4例,均获得完全缓解。完全缓解持续时间最长者已达15个月。HOP方案对急性早幼粒细胞白血病相当敏感,但应用剂量宜小,疗程宜有间歇,避免药力过猛,使骨髓受抑翻过重或者异形幼稚细胞破坏,细胞颗粒大量释放而促发DIC和严重出血。副作用较轻,值得今后继续观察。
This article reports the use of harringtonine combined with chemotherapy (HOP program) in the treatment of acute promyelocytic leukemia in 4 cases, were completely relieved. The longest complete remission has lasted 15 months. HOP program for acute promyelocytic leukemia is quite sensitive, but the application dose should be small, the treatment should be intermittent, to avoid over-force, so that bone marrow obstruction turned overweight or abnormal shape of naive cells destroyed, a large number of cellular particles to promote DIC and Severe bleeding. Less side effects, it is worth continuing to observe in the future.