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老年原发性高血压患者中,单纯收缩期高血压更常见,是心血管疾病的重要危险因素,主要归因于弹性动脉僵硬度增加。年龄和血压水平是影响动脉弹性功能的重要因素,而大动脉弹性功能减退是高血压患者并发心脑血管意外的重要病理生理基础,动脉壁结构和功能的改变是高血压疾病发生发展的早期标志。尽管不同种类降压药物在降压水平上总体差别很小,但对大动脉顺应性的改变有所不同。
Among elderly patients with essential hypertension, isolated systolic hypertension is more common and is an important risk factor for cardiovascular disease, mainly due to an increase in elastic arterial stiffness. Age and blood pressure level are important factors affecting arterial elasticity. Aortic insufficiency is an important pathophysiological basis of cardiovascular and cerebrovascular accidents in hypertensive patients. Changes in arterial wall structure and function are early signs of the development of hypertension. Although different types of antihypertensive drugs generally have little difference in blood pressure levels, changes in arterial compliance differ.