目的：对咖啡酸和阿魏酸以及两者化学衍生物肉桂酰胺类似物Ｎ３（５甲基异吓恶唑）基３，４二羟基肉桂酰胺（化合物１）和Ｎ４安替比林基４羟基３甲氧基肉桂酰胺（化合物２）拮抗内皮素１（ＥＴ１）的缩血管及致血管平滑肌细胞增殖效应进行了初步研究。方法：用这四种化合物对ＥＴ１缩血管及致血管平滑肌细胞增殖作用的拮抗效应拮抗进行了研究。结果：咖啡酸和阿魏酸及其衍生物对ＥＴ１缩血管及致血管平滑肌细胞增殖效应有明显的拮抗作用，该作用具剂量依赖性，经药效动力学分析，阿魏酸及其衍生物的拮抗活性显著大于咖啡酸及其衍生物；这四种化合物能剂量依赖性地抑制ＥＴ１致血管平滑肌细胞增殖作用。结论：咖啡酸和阿魏酸及其衍生物为一类新的ＥＴ拮抗剂。 OBJECTIVE: To investigate the effects of caffeic acid, ferulic acid and their derivatives Cinnamate N3 (5methylisoxazolide)  3,4dihydroxycinnamide (Compound 1) and N4antipyrine Bilin base  4  hydroxy  3  methoxy cinnamide (compound 2) antagonistic endothelin  1 (ET  1) vasoconstriction and vascular smooth muscle cell proliferation was studied. Methods: Antagonistic antagonistic effect of these four compounds on the proliferation of ET 1 vasoconstrictor and vascular smooth muscle cells were studied. Results: Caffeic acid and ferulic acid and their derivatives on ET 1 vasoconstrictor and vascular smooth muscle cell proliferation was significantly antagonistic effect, the role of a dose-dependent, pharmacodynamics analysis, ferulic acid and its Derivatives antagonistic activity was significantly greater than caffeic acid and its derivatives; these four compounds can dose-dependent inhibition of ET 1 induced vascular smooth muscle cell proliferation. Conclusion: Caffeic acid and ferulic acid and their derivatives are a new class of ET antagonists.