目前对放射性肾病有一些研究 ,但对其发生机理不很明确 ,现有的体外照射动物肾脏的方法存在定位不准确和肾外组织的损伤。本研究用手术方法将大鼠双肾暴露体外后进行γ射线照射 ,并通过光镜和电镜观察电离辐射肾损伤的病理特点 ,以RT PCR方法研究相关基因表达量的改变 ,为放射 At present, there are some studies on radiation nephropathy, but the mechanism of its occurrence is not clear. The existing methods of in vitro irradiation of animal kidneys have inaccurate localization and damage to extrarenal tissues. In this study, the rats were exposed to γ-rays after exposure to both kidneys in vitro. The pathological features of ionizing radiation-induced renal injury were observed by light and electron microscopy. The changes of related gene expression were studied by RT-PCR.