目的观察氟桂嗪辅助治疗儿童癫的疗效及其对癫患儿脑脊液钙含量的影响。方法 64例癫患儿随机分为两组 ,治疗组及对照组各 3 2例。两组均按不同发作类型应用抗癫药物治疗 ,治疗组加用氟桂嗪口服 ,5 mg/次 ,每晚 1次 ,连服 3个月。观察临床疗效并测定癫发作后 3、72小时脑脊液钙含量 ,同时与 3 0例健康儿童进行对照研究。结果治疗组 3 2例中 14例发作减少≥ 75 %(4 3 .8% ) ,10例发作减少≥ 5 0 % (3 1.2 % ) ;对照组 3 2例中 8例发作减少≥ 75 % (2 5 % ) ,8例发作减少≥ 5 0 % (2 5 % )。两组临床总有效率分别为 75 %、5 0 % ,有显著性差异 (P<0 .0 5 )。 64例患儿癫发作后 3小时和 72小时脑脊液 Ca2 + 含量明显低于健康对照组 (P<0 .0 1) ;而加用氟桂嗪的治疗组已恢复到健康组水平 (P>0 .0 5 )。结论氟桂嗪联合抗癫药物治疗儿童癫疗效更好 Objective To investigate the efficacy of flunarizine in the treatment of children with epilepsy and its effect on the calcium content of cerebrospinal fluid in children with epilepsy. Methods 64 cases of epilepsy were randomly divided into two groups, the treatment group and the control group of 32 cases. Both groups were treated with antiepileptic drugs according to different seizure types. The treatment group was treated with flunarizine orally at 5 mg once daily for 3 months. The clinical efficacy was observed and the cerebrospinal fluid calcium content was measured 3 and 72 hours after the onset of epilepsy. At the same time, 30 healthy children were studied. Results In the treatment group, the onset of attack in 14 out of 32 patients was reduced by 75% (43.8%) and in 10 patients with a reduction of 50% (32.2%). In the control group, 8 out of 32 patients were reduced by 75% 25%), and the reduction in 8 cases was ≥50% (25%). The total effective rate of the two groups was 75%, 50%, there was a significant difference (P <0. 05). The content of Ca2 + in cerebrospinal fluid in 64 infants with epilepsy was significantly lower than that in healthy controls at 3h and 72h (P <0.01), while those treated with flunarizine returned to normal levels (P> 0 .0 5). Conclusion Flunarizine combined with anti-epileptic drugs in children with epilepsy better