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目的 分析溃疡性结肠炎 (UC)伴随的肠外表现 ,探讨其与病变部位和疾病程度之间的关系。方法 采用 χ2 检验方法对 392例UC患者进行回顾性分析。结果 392例UC患者中 ,82例(2 0 9%)有肠外表现 ,其中 34例 (8 7%)有 1种以上肠外表现 ;全结肠型与左半结肠型UC患者肠外表现的发生率均较单纯直肠型者增高 (P <0 0 5 ) ,其中全结肠型的发生率最高 ,左半结肠型次之 ,单纯直肠型最低 ,呈递减趋势 ,但前二者间差异无显著性 (P >0 0 5 ) ;各种常见肠外表现的发生率在重度UC患者较轻度明显升高 (P <0 0 5 ) ,从轻度、中度到重度呈递增趋势 ;除强直性脊柱炎、原发性硬化性胆管炎等外 ,多数肠外表现的发生与UC活动性密切相关 ,经氨基水杨酸类和 (或 )皮质类固醇治疗后消失。结论 UC患者肠外表现发生率较高 ,累及的部位依次为关节、肝胆、皮肤、口腔和眼睛。UC肠外表现的发生与病变部位和炎症程度密切相关。多数肠外表现与UC活动性相关 ,但与UC预后无明显关系。
Objective To analyze the parenteral manifestations associated with ulcerative colitis (UC) and to explore its relationship with the lesion location and degree of disease. Methods The χ2 test was used to analyze 392 UC patients. Results Of the 392 UC patients, 82 (20.9%) had parenteral manifestations, of which 34 (87%) had more than one type of parenteral manifestations; all colon-type and left-colon type UC patients had parenteral manifestations (P <0 05). The incidence of total colon was the highest, the incidence of left colon followed by that of pure rectum was the lowest, but the difference was not significant (P> 0.05). The incidences of various common extranodal manifestations in patients with severe UC were slightly increased (P <0.05), and increased from mild to moderate to severe; Ankylosing spondylitis, primary sclerosing cholangitis, etc., most of the occurrence of parenteral manifestations are closely related to the activity of UC, after aminosalicylates and (or) corticosteroid treatment disappeared. Conclusions The incidence of parenteral manifestations in UC patients is high, involving the joints, liver and gall bladder, skin, mouth and eyes in sequence. The occurrence of parenteral manifestations of UC is closely related to the lesion site and degree of inflammation. The majority of extraintestinal manifestations were associated with UC activity but not with UC prognosis.