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采用He常压辉光放电等离子体(APGDP)处理有机硅薄膜材料表面并引发2-甲基丙烯酰氧乙基磷酰胆碱(MPC)在其表面接枝聚合。通过ATR-FTIR对接枝前后膜表面的结构进行表征分析,确定MPC共价接枝到材料表面。改性后膜表面的接触角由101°下降到54°,在室温下保存15天后仍维持在58°左右,表明接枝MPC后有机硅材料获得高亲水性的表面,并能使这一性质较好地保持。接枝前后膜的力学性质变化不大。体外血小板粘附实验表明,接枝MPC后的材料表面能够显著抑制血小板的粘附和聚集,具有优良的血液相容性,可以作为一种新型医用生物弹性体。
The surface of the silicon thin film material was treated with atmospheric pressure glow discharge plasma (APGDP) to initiate the graft polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC). The structure of the membrane surface before and after grafting was characterized by ATR-FTIR to confirm that the MPC was covalently grafted onto the surface of the material. After the modification, the contact angle of the membrane surface decreased from 101 ° to 54 °, and remained at about 58 ° after 15 days at room temperature, indicating that the organic silicon material obtained after grafting MPC has a high hydrophilic surface and can make this Maintains well. The mechanical properties of the membrane before and after grafting changed little. In vitro platelet adhesion experiments show that grafted MPC material surface can significantly inhibit platelet adhesion and aggregation, has excellent blood compatibility, can be used as a new medical bio-elastomer.